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Multifaceted Roles of Guanylate-Binding Proteins in Cancer

7 Jun 2025

Abstract excerpt

Guanylate-binding proteins (GBPs), encompassing GBP1 through GBP7 in humans, are interferon-inducible large GTPases of the dynamin superfamily, renowned for their pivotal roles in cell-autonomous immunity against intracellular pathogens such as viruses, bacteria, and protozoa. By recognizing pathogen-associated molecular patterns (PAMPs) and danger-associated molecular patterns (DAMPs), GBPs orchestrate lysosomal...

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PMID: 40564939
DOI: 10.3390/ijms26125477

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