Article

Proteostasis sustains T cell differentiation potential and tumor-infiltrating lymphocyte function

2026-02-10

Abstract excerpt

<h4>Summary</h4> Tumor-infiltrating lymphocytes (TIL) often fail to restrain tumor growth due to progressive differentiation to an ‘exhausted’ state. In healthy tissues, tissue-resident memory T cells (T RM ) maintain protection for years, and patient tumors that contain TIL with T RM features are associated with better prognosis. Proteomic and transcriptomic profiling of T cell populations identified proteosta...

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Literature Corpus work: ca799f81-ef4d-5d56-bedb-3b170dc26180
DOI: 10.64898/2026.02.08.704716

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