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Cellular Reprogramming of H3K27M Pediatric High-Grade Glioma to Neuron-like State

2025-08-07

Abstract excerpt

This study explores the cell fate reprogrammability of H3K27M-mutant pediatric high-grade gliomas (pHGG) using neuronal transdifferentiation as a potential targeted therapy. We treated the BT245 patient-derived glioma cell line with pharmacological combinations targeting neuronal differentiation pathways and performed bulk RNA sequencing to characterize gene expression patterns driving cell fate transitions. Our f...

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Literature Corpus work
2e8338ed-7ae8-53e3-a4e4-05d81ce2ec8f
DOI
10.1101/2025.08.05.668496
Open publication

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