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Article

A Compendium of Syngeneic, Transplantable Pediatric High-Grade Glioma Models Reveals Subtype-Specific Therapeutic Vulnerabilities.

Cancer discovery - 7 Jul 2023

McNicholas Michael, De Cola Antonella, Bashardanesh Zahedeh, Foss Amelia, Lloyd Cameron B, Hébert Steven, Faury Damien, Andrade Augusto Faria, Jabado Nada, Kleinman Claudia L, Pathania Manav

Abstract excerpt

Pediatric high-grade gliomas (pHGG) are lethal, incurable brain tumors frequently driven by clonal mutations in histone genes. They often harbor a range of additional genetic alterations that correlate with different ages, anatomic locations, and tumor subtypes. We developed models representing 16 pHGG subtypes driven by different combinations of alterations targeted to specific brain regions. Tumors developed...

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Identifiers

PMID: 37011011
DOI: 10.1158/2159-8290.CD-23-0004
PMCID: PMC10326601

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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