Article

H3K4-H3K9 Histone Methylation Patterns and Oncofetal Developmental Networks as Drivers of Cell Fate Decisions in Pediatric High-Grade Gliomas

2024-12-30

Abstract excerpt

<h4>ABSTRACT</h4> This study employs systems medicine approaches, including complex networks and machine learning-driven discovery, to identify key biomarkers governing phenotypic plasticity in pediatric high-grade gliomas (pHGGs), namely, IDHWT glioblastoma and H3K27M diffuse intrinsic pontine glioma (DIPG). By integrating single-cell transcriptomics and histone mass cytometry data, we conceptualize these aggres...

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Literature Corpus work: 4de47dd8-8d38-5e56-b112-28b18089182f
DOI: 10.1101/2024.12.29.630486

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H3K4-H3K9 Histone Methylation Patterns and Oncofetal Developmental Networks as Drivers of Cell Fate Decisions in Pediatric High-Grade GliomasDOI 10.1101/2024.12.29.630486Read

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