Article

The fungal expel of 5-fluorocytosine derived fluoropyrimidines mitigates its antifungal activity and generates a cytotoxic environment

2022-08-24

Abstract excerpt

Invasive aspergillosis remains one of the most devastating fungal diseases and is predominantly linked to infections caused by the opportunistic human mold pathogen Aspergillus fumigatus . Major treatment regimens for the disease comprise the administration of antifungals belonging to the azole, polyene and echinocandin drug class. The prodrug 5-fluorocytosine (5FC), which is the only representative of a fourth c...

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Literature Corpus work: 2e76d840-2daa-57fa-9dd8-b1cfdf9b72f8
DOI: 10.1101/2022.08.24.504767

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