Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

tRNA hypomodification facilitates 5-fluorocytosine resistance via cross-pathway control system activation in Aspergillus fumigatus

23 Dec 2024

Abstract excerpt

Increasing antifungal drug resistance is a major concern associated with human fungal pathogens like Aspergillus fumigatus. Genetic mutation and epimutation mechanisms clearly drive resistance, yet the epitranscriptome remains relatively untested. Here, deletion of the A. fumigatus transfer RNA (tRNA)-modifying isopentenyl transferase ortholog, Mod5, led to altered stress response and unexpected resistance...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Fungal Infections and Studies
Share to Infective Endocarditis Diagnosis and Management
Share to Peptidase Inhibition and Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39711467
DOI: 10.1093/nar/gkae1205

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

tRNA hypomodification facilitates 5-fluorocytosine resistance via cross-pathway control system activation in Aspergillus fumigatusPMID 39711467Read ↗

tRNA hypomodification facilitates 5-fluorocytosine resistance via cross-pathway control system activation in <i>Aspergillus fumigatus</i>Semantic proximity Read ↗

The interactome of <i>Cryptococcus neoformans</i> Rmt5 reveals multiple regulatory points in fungal cell biology and pathogenesisSemantic proximity Read ↗

Cross-feeding affects the target of resistance evolution to an antifungal drugSemantic proximity Read ↗

NMD-mediated control of Tor influences adaptation to nutrient and temperature conditions in <i>Cryptococcus neoformans</i>Semantic proximity Read ↗

Redefining Pleiotropic Drug Resistance in a Pathogenic Yeast: Pdr1 Functions as a Sensor of Cellular Stresses in <i>Candida glabrata</i>Semantic proximity Read ↗

Redefining pleiotropic drug resistance in a pathogenic yeast: Pdr1 functions as a sensor of cellular stresses in Candida glabrataSemantic proximity Read ↗

Rapid in vitro evolution of flucytosine resistance in Candida aurisSemantic proximity Read ↗

Broad antifungal resistance mediated by RNAi-dependent epimutation in the basal human fungal pathogen Mucor circinelloidesSemantic proximity Read ↗

Broad antifungal resistance mediated by RNAi-dependent epimutation in the basal human fungal pathogen Mucor circinelloidesSemantic proximity Read ↗

Regulation of gliotoxin biosynthesis and protection in Aspergillus speciesSemantic proximity Read ↗

Asymmetrical dose-responses shape the evolutionary trade-off between antifungal resistance and nutrient useSemantic proximity Read ↗

Regulation of gliotoxin biosynthesis and protection in <i>Aspergillus</i> speciesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.