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The distinct biochemical property enables thymidylate kinase as a drug target and participates in pyrimidine drug sensitivity in <i>Candida albicans</i>

2018-11-09

Abstract excerpt

The ability to overcome drug resistance in outbreaks of Candida albicans infection is an unmet need in health management. Here, we investigated CDC8 , which encodes thymidylate kinase (TMPK), as a potential drug target for the treatment of C. albicans infection. In this study, we found that the specific region spanning amino acids 106-123, namely, the Ca-loop of C. albicans TMPK (CaTMPK) contributes to the hyp...

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Literature Corpus work
13dc7a63-0904-5682-8782-54b254665f02
DOI
10.1101/466938
Open publication

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The distinct biochemical property enables thymidylate kinase as a drug target and participates in pyrimidine drug sensitivity in <i>Candida albicans</i>DOI 10.1101/466938
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