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Article

Moderate levels of 5-fluorocytosine cause the emergence of high frequency resistance in cryptococci.

Nature communications - 8 Jun 2021

Chang Yun C, Lamichhane Ami Khanal, Cai Hongyi, Walter Peter J, Bennett John E, Kwon-Chung Kyung J

Abstract excerpt

The antifungal agent 5-fluorocytosine (5-FC) is used for the treatment of several mycoses, but is unsuitable for monotherapy due to the rapid development of resistance. Here, we show that cryptococci develop resistance to 5-FC at a high frequency when exposed to concentrations several fold above the minimal inhibitory concentration. The genomes of resistant clones contain alterations in genes relevant as well as...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34103502
DOI: 10.1038/s41467-021-23745-1
PMCID: PMC8187385

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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