Article

Targeting methionine synthase in a fungal pathogen causes a metabolic imbalance that impacts cell energetics, growth and virulence

2020-06-05

Abstract excerpt

<h4>ABSTRACT</h4> There is an urgent need to develop novel antifungals to tackle the threat fungal pathogens pose to human health. In this work, we have performed a comprehensive characterisation and validation of the promising target methionine synthase (MetH). We uncover that in Aspergillus fumigatus the absence of this enzymatic activity triggers a metabolic imbalance that causes a reduction in intracellular...

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Identifiers and source

Literature Corpus work: 1db32233-e269-5fe4-87e1-05d0a2dac590
DOI: 10.1101/2020.06.04.131862

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