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Article

Mutational Analysis of Flucytosine Resistance in <i>Candida glabrata</i>

8 Sept 2010

Abstract excerpt

The antifungal flucytosine (5-fluorocytosine [5FC]) is a prodrug metabolized to its toxic form, 5-fluorouracil (5FU), only by organisms expressing cytosine deaminase. One such organism is Candida glabrata, which has emerged as the second most common agent of bloodstream and mucosal candidiasis. This emergence has been attributed to the high rate at which C. glabrata develops resistance to azole antifungals. As an...

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PMID: 20823283
DOI: 10.1128/aac.00605-10

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