Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic prerequisites for additive or synergistic actions of 5-fluorocytosine and fluconazole in baker's yeast.

Microbiology (Reading, England) - 1 Oct 2008

Paluszynski John P, Klassen Roland, Meinhardt Friedhelm

Abstract excerpt

During applications of 5-fluorocytosine (5FC) and fluconazole (FLC), additive or synergistic action may even occur when primary resistance to 5FC is established. Here, we analysed conjoint drug action in Saccharomyces cerevisiae strains deficient in genes known to be essential for 5FC or FLC function. Despite clear primary resistance, residual 5FC activity and additive 5FC+FLC action in cells lacking cytosine...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antifungal Agents
Share to Cytosine Deaminase
Share to Drug Resistance, Fungal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Synergism

Share to Fluconazole

Share to Oxidoreductases

Share to Pentosyltransferases

Share to Transformation, Genetic

Source

Identifiers

PMID: 18832321
DOI: 10.1099/mic.0.2008/020107-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic prerequisites for additive or synergistic actions of 5-fluorocytosine and fluconazole in baker's yeast.PMID 18832321Read ↗

Cross-feeding affects the target of resistance evolution to an antifungal drugSemantic proximity Read ↗

Cross-feeding affects the target of resistance evolution to an antifungal drugSemantic proximity Read ↗

Moderate levels of 5-fluorocytosine cause the emergence of high frequency resistance in cryptococci.Semantic proximity Read ↗

The fungal expel of 5-fluorocytosine derived fluoropyrimidines mitigates its antifungal activity and generates a cytotoxic environmentSemantic proximity Read ↗

Mutational Analysis of Flucytosine Resistance in <i>Candida glabrata</i>Semantic proximity Read ↗

Efflux-mediated resistance to fluconazole could be modulated by sterol homeostasis in Saccharomyces cerevisiae.Semantic proximity Read ↗

<i>URA6</i> mutations provide an alternative mechanism for 5-FOA resistance in <i>Saccharomyces cerevisiae</i>Semantic proximity Read ↗

Asymmetrical dose-responses shape the evolutionary trade-off between antifungal resistance and nutrient useSemantic proximity Read ↗

Antagonism between two mechanisms of antifungal drug resistance.Semantic proximity Read ↗

Multiple or pleiotropic drug resistance in yeast.Semantic proximity Read ↗

5-fluorocytosine resistance is associated with hypermutation and alterations in capsule biosynthesis in Cryptococcus.Semantic proximity Read ↗

Molecular mechanism of flucytosine resistance in Candida lusitaniae: contribution of the FCY2, FCY1, and FUR1 genes to 5-fluorouracil and fluconazole cross-resistance.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.