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Article

The complex mechanism of antimycobacterial action of 5-fluorouracil.

Chemistry & biology - 22 Jan 2015

Singh Vinayak, Brecik Miroslav, Mukherjee Raju, Evans Joanna C, Svetlíková Zuzana, Blaško Jaroslav, Surade Sachin, Blackburn Jonathan, Warner Digby F, Mikušová Katarína, Mizrahi Valerie

Abstract excerpt

A combination of chemical genetic and biochemical assays was applied to investigate the mechanism of action of the anticancer drug 5-fluorouracil (5-FU), against Mycobacterium tuberculosis (Mtb). 5-FU resistance was associated with mutations in upp or pyrR. Upp-catalyzed conversion of 5-FU to FUMP was shown to constitute the first step in the mechanism of action, and resistance conferred by nonsynonymous SNPs in...

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PMID: 25544046
DOI: 10.1016/j.chembiol.2014.11.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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