Article

A water-pinning hotspot drives templated tau aggregation

2026-08-09

Abstract excerpt

Tau assembles into fibrillar aggregates that are pathological hallmarks of a group of neurodegenerative diseases collectively called tauopathies. Templated aggregation of naïve tau to seeding-competent fibrils that proceed from cell to cell is a key driver of prion-like progression of tauopathies. This study tests the hypothesis that tau, an intrinsically disordered protein (IDP), achieves in-register stacking to...

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Literature Corpus work: 2e4c93e7-feb9-55db-bd5c-99e4a5a24ee8
DOI: 10.64898/2026.08.04.742883

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