Article
Post-translational modification sites are present in hydrophilic cavities of alpha-synuclein, tau, FUS, and TDP-43 fibrils: A molecular dynamics study.
Proteins - 1 Jul 2024
Kochen Noah Nathan, Seaney Darren, Vasandani Vivek, Murray Marguerite, Braun Anthony R, Sachs Jonathan N
Abstract excerpt
Hydration plays a crucial role in the refolding of intrinsically disordered proteins into amyloid fibrils; however, the specific interactions between water and protein that may contribute to this process are still unknown. In our previous studies of alpha-synuclein (aSyn), we have shown that waters confined in fibril cavities are stabilizing features of this pathological fold; and that amino acids that hydrogen...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.