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Article

Threonine Cavities Are Targetable Motifs That Control Alpha-Synuclein Fibril Growth.

ACS chemical neuroscience - 7 Sept 2022

Nathan Kochen Noah, Vasandani Vivek, Seaney Darren, Pandey Anil K, Walters Michael A, Braun Anthony R, Sachs Jonathan N

Abstract excerpt

Recent high-resolution structures of alpha-synuclein (aSyn) fibrils offer promise for rational approaches to drug discovery for Parkinson's disease and Lewy body dementia. Harnessing the first such structures, we previously used molecular dynamics and free energy calculations to suggest that threonines 72 and 75─which line water-filled cavities within the fibril stacks─may be of central importance in stabilizing...

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PMID: 36001084
DOI: 10.1021/acschemneuro.2c00327
PMCID: PMC9906799

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