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Article

Prion and water: tight and dynamical hydration sites have a key role in structural stability.

Proceedings of the National Academy of Sciences of the United States of America - 24 May 2005

De Simone Alfonso, Dodson Guy G, Verma Chandra S, Zagari Adriana, Fraternali Franca

Abstract excerpt

The propensity to form fibril in disease-related proteins is a widely studied phenomenon, but its correlation, if any, with structural characteristics of the associated proteins is not clearly understood. However, the observation has been made that some proteins that readily form amyloid have a significant number of backbone H bonds that are exposed to solvent molecules, suggesting that these regions have a...

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Identifiers

PMID: 15894615
DOI: 10.1073/pnas.0501748102
PMCID: PMC1140432

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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