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Model-based analysis of N-glycosylation in Chinese hamster ovary cells

9 May 2017

Abstract excerpt

The Chinese hamster ovary (CHO) cell is the gold standard for manufacturing of glycosylated recombinant proteins for production of biotherapeutics. The similarity of its glycosylation patterns to the human versions enable the products of this cell line favorable pharmacokinetic properties and lower likelihood of causing immunogenic responses. Because glycan structures are the product of the concerted action of...

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PMID: 28486471
DOI: 10.1371/journal.pone.0175376

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