Article

Mathematical modelling of mutant glycoprotein fate in the ER

2026-03-19

Abstract excerpt

Background The endoplasmic reticulum (ER) coordinates glycoprotein quality control through competing pathways: ER quality control (ERQC) and ER-associated degradation (ERAD). The fate of a glycoprotein is encoded by its N -glycan structure, which acts as a molecular barcode for ER surveillance. Modulation of ERQC/ERAD can increase leakage of responsive ( i.e. , non-inactive) glycoprotein mutants that remain misf...

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Literature Corpus work: d9459fca-e48f-55ad-887d-b2c09084818c
DOI: 10.12688/wellcomeopenres.25558.1

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