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Article

Dynamics of immature mAb glycoform secretion during CHO cell culture: An integrated modelling framework

8 Jan 2016

Abstract excerpt

Ensuring consistent glycosylation-associated quality of therapeutic monoclonal antibodies (mAbs) has become a priority in pharmaceutical bioprocessing given that the distribution and composition of the carbohydrates (glycans) bound to these molecules determines their therapeutic efficacy and immunogenicity. However, the interaction between bioprocess conditions, cellular metabolism and the intracellular process...

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PMID: 26743760
DOI: 10.1002/biot.201400663

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