Heterogeneous Tumor-Immune Microenvironments among Differentially Growing Metastases in an Ovarian Cancer Patient.

doi:10.1016/j.cell.2017.07.025

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Article

Heterogeneous Tumor-Immune Microenvironments among Differentially Growing Metastases in an Ovarian Cancer Patient.

Cell - 24 Aug 2017

Jiménez-Sánchez Alejandro, Memon Danish, Pourpe Stephane, Veeraraghavan Harini, Li Yanyun, Vargas Hebert Alberto, Gill Michael B, Park Kay J, Zivanovic Oliver, Konner Jason, Ricca Jacob, Zamarin Dmitriy, Walther Tyler, Aghajanian Carol, Wolchok Jedd D, Sala Evis, Merghoub Taha, Snyder Alexandra, Miller Martin L

Abstract excerpt

We present an exceptional case of a patient with high-grade serous ovarian cancer, treated with multiple chemotherapy regimens, who exhibited regression of some metastatic lesions with concomitant progression of other lesions during a treatment-free period. Using immunogenomic approaches, we found that progressing metastases were characterized by immune cell exclusion, whereas regressing and stable metastases...

Topics

Antigens, Neoplasm
Cystadenocarcinoma, Serous
Female
Gene Expression Regulation, Neoplastic
Humans
Mutation
Neoplasm Metastasis
Ovarian Neoplasms
T-Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Transcriptome

Tumor Microenvironment

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PMID: 28841418
DOI: 10.1016/j.cell.2017.07.025
PMCID: PMC5589211

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