A crucial role for Olig2 in white matter astrocyte development.

doi:10.1242/dev.02847

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Article

A crucial role for Olig2 in white matter astrocyte development.

Development (Cambridge, England) - 1 May 2007

Cai Jeff, Chen Ying, Cai Wen-Hui, Hurlock Edward C, Wu Heng, Kernie Steven G, Parada Luis F, Lu Q Richard

Abstract excerpt

The mechanisms underlying astrocyte heterogeneity in the developing mouse brain are poorly understood. The bHLH transcription factor Olig2 is essential for motoneuron and oligodendrocyte formation; however, its role in astrocyte development remains obscure. During cortical development, Olig2 is transiently expressed in immature developing astrocytes at neonatal stages and is progressively downregulated in...

Topics

Animals
Astrocytes
Basic Helix-Loop-Helix Transcription Factors
Brain
Cell Differentiation
Cell Lineage
Developmental Biology
Gene Expression Regulation, Developmental
Glial Fibrillary Acidic Protein
In Situ Hybridization

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mice, Knockout

Mice, Mutant Strains

Mutation

Nerve Tissue Proteins

Oligodendrocyte Transcription Factor 2

Spinal Cord

Source

Open in PubMed

Identifiers

PMID: 17428828
DOI: 10.1242/dev.02847

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GFAP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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