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Orchestrating the Acquisition of Oligodendrocyte Precursor Cell versus Olfactory Bulb Interneuron Fates through <i>Olig1/2</i> during Mammalian Cortical Gliogenesis and Gliomagenesis

2024-11-14

Abstract excerpt

The hijacking of developmental gliogenesis programs is a hallmark of glioblastoma (GBM), in which glial precursor cells (GPCs) typically differentiate into both neurons and glial cells. In GBM, this process is disrupted, leading to the overproduction of proliferative glial-like cells. Our study demonstrates that the knockout of Olig1/2 in both normal development and gliomagenesis causes GPCs to shift from generat...

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Literature Corpus work
2dd09a19-1bef-5751-a73d-80af60c7f376
DOI
10.1101/2024.11.11.623106
Open publication

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Orchestrating the Acquisition of Oligodendrocyte Precursor Cell versus Olfactory Bulb Interneuron Fates through <i>Olig1/2</i> during Mammalian Cortical Gliogenesis and GliomagenesisDOI 10.1101/2024.11.11.623106
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