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Article

A latent lineage potential in resident neural stem cells enables spinal cord repair

2 Oct 2020

Abstract excerpt

Injuries to the central nervous system (CNS) are inefficiently repaired. Resident neural stem cells manifest a limited contribution to cell replacement. We have uncovered a latent potential in neural stem cells to replace large numbers of lost oligodendrocytes in the injured mouse spinal cord. Integrating multimodal single-cell analysis, we found that neural stem cells are in a permissive chromatin state that...

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PMID: 33004487
DOI: 10.1126/science.abb8795

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