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Mitochondrial Hsp60/10 Client Protein Decline Reveals Braak/Tau- and Cognition-Linked Proteostasis Vulnerabilities in Alzheimer’s Disease

2026-06-30

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Alzheimer’s disease (AD) is classically defined by amyloid and tau pathology and is accompanied by broad disruptions in proteostasis. Heat shock proteins (HSPs) help maintain proteostasis, yet mitochondrial chaperone systems remain comparatively underexplored in AD. Hsp60 and Hsp10 form a mitochondrial chaperonin complex that folds dozens of AD-implicated mitochondrial prote...

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Literature Corpus work: 2e2c4f84-4693-5010-9e1e-266eb9d22f7f
DOI: 10.64898/2026.06.25.734545

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