Back to search

Article

Transcriptional Coordination between Mitochondrial and Nuclear Genomes for Oxidative Phosphorylation Is Disrupted in Alzheimer’s Brain

2022-10-10

Abstract excerpt

Decline in mitochondrial function and oxidative phosphorylation in Alzheimer’s disease (AD) are well documented which led us to investigate coordination between mitochondrial DNA (mtDNA) and nuclear DNA (nDNA) genomes specific to oxidative phosphorylation (OXPHOS). Using AMP-AD mtDNA and nDNA datasets, regression analyses of OXPHOS transcriptomic, proteomic profiles and AD clinical biomarkers were conducted. Outco...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
3fa3a033-3961-54ec-b682-8393c3788dfa
DOI
10.21203/rs.3.rs-2122232/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Transcriptional Coordination between Mitochondrial and Nuclear Genomes for Oxidative Phosphorylation Is Disrupted in Alzheimer’s BrainDOI 10.21203/rs.3.rs-2122232/v1
Transcriptomic and epigenomic landscapes of Alzheimer's disease evidence mitochondrial-related pathwaysSemantic proximity
The Role of Mitochondrial genome abundance in Alzheimer’s DiseaseSemantic proximity
Oxidative-phosphorylation genes from the mitochondrial and nuclear genomes co-express in all human tissues except for the ancient brainSemantic proximity
Decreased expression of nuclear and mitochondrial DNA-encoded genes of oxidative phosphorylation in association neocortex in Alzheimer diseaseSemantic proximity
The role of mitochondrial genome abundance in Alzheimer's diseaseSemantic proximity
Mitochondrial DNA Copy Numbers in Pyramidal Neurons are Decreased and Mitochondrial Biogenesis Transcriptome Signaling is Disrupted in Alzheimer's Disease HippocampiSemantic proximity
Human brain mitochondrial-nuclear cross-talk is cell-type specific and is perturbed by neurodegenerationSemantic proximity
Deciphering novel mitochondrial signatures: multi-omics analysis uncovers cross-disease markers and oligodendrocyte pathways in Alzheimer’s disease and glioblastomaSemantic proximity
Nuclear but not mitochondrial‐encoded oxidative phosphorylation genes are altered in aging, mild cognitive impairment, and Alzheimer's diseaseSemantic proximity
Mitochondria and Alzheimer’s Disease: the Role of Mitochondrial Genetic VariationSemantic proximity
Mitochondrial-nuclear cross-talk in the human brain is modulated by cell type and perturbed in neurodegenerative diseaseSemantic proximity
Blood-derived mitochondrial DNA copy number is associated with Alzheimer disease, Alzheimer-related biomarkers and serum metabolitesSemantic proximity
Select a neighboring publication to make it the new centre.