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Alzheimer Cells on Their Way to Derailment Show Selective Changes in Protein Quality Control Network

20 Nov 2020

Abstract excerpt

Alzheimer's Disease is driven by protein aggregation and is characterized by accumulation of Tau protein into neurofibrillary tangles. In healthy neurons the cellular protein quality control is successfully in charge of protein folding, which raises the question to which extent this control is disturbed in disease. Here, we describe that brain cells in Alzheimer's Disease show very specific derailment of the...

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PMID: 33330614
DOI: 10.3389/fmolb.2020.00214

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