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Article

Prevalence and Clinical Phenotype of Quadruple Misfolded Proteins in Older Adults.

JAMA neurology - 1 Oct 2020

Karanth Shama, Nelson Peter T, Katsumata Yuriko, Kryscio Richard J, Schmitt Frederick A, Fardo David W, Cykowski Matthew D, Jicha Gregory A, Van Eldik Linda J, Abner Erin L

Abstract excerpt

Importance: Quadruple misfolded proteins (tau neurofibrillary tangles, amyloid-β [Aβ], α-synuclein, and transactive response DNA-binding protein 43 [TDP-43]) in the same brain are relatively common in aging. However, the clinical presentation, associated factors, frequency in community-based cohorts, genetic characteristics, and cognitive trajectories associated with the quadruple misfolded proteins phenotype are...

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Identifiers

PMID: 32568358
DOI: 10.1001/jamaneurol.2020.1741
PMCID: PMC7309572

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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