Article

Synergistic MAPT mutations as a platform to uncover modifiers of tau pathogenesis

2025-02-08

Abstract excerpt

The natively unfolded tau (MAPT) protein is extremely soluble, which poses challenges when modeling neurofibrillary tangle (NFT) pathology in Alzheimers disease (AD). To overcome this hurdle, we combined P301L and S320F mutations (PL-SF) to generate a rapid and reliable tau pathology platform to expedite the discovery of factors that modify tau aggregation. Using this model, we evaluated heat-shock proteins (Hsp),...

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Literature Corpus work: 4402ded6-c76c-5466-a9ea-5b2bccb03dac
DOI: 10.1101/2025.02.07.636933

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