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The chaperones HSP90AA1, HSP90AB1 and BAG3 are specifically distributed among human hippocampal subfields during different Alzheimer's disease stages

26 May 2025

Abstract excerpt

Alzheimer's disease (AD) includes amyloid-β plaques and tau tangles as associated proteinopathies. Tau aggregates appear in a sequential and predictable manner, defined by six stages (Braak stages I-VI) of neuropathological diagnosis, with the hippocampus, particularly the CA1 subfield, being involved in the early stages. Chaperones play a key role in amyloid-β and tau misfolding. Chaperones constitute a vast...

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PMID: 40436281
DOI: 10.1016/j.nbd.2025.106971

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