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Alzheimer's Disease and Molecular Chaperones: Current Knowledge and the Future of Chaperonotherapy

19 May 2016

Abstract excerpt

BACKGROUND: Alzheimer's disease (AD) is a dementia, a neurodegenerative condition, and a protein-misfolding disease or proteinopathy, characterized by protein deposits, extracellular plaques and intracellular neurofibrillary tangles, which contain the AD's typical pathological proteins, abnormal β-amyloid and hyperphosphorylated tau, respectively, and are located predominantly in the cortex of the frontal,...

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PMID: 27189602
DOI: 10.2174/1381612822666160518141437

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