Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human skin aging is associated with increased expression of the histone variant H2A.J in the epidermis

1 Apr 2021

Abstract excerpt

Cellular senescence is an irreversible growth arrest that occurs as a result of damaging stimuli, including DNA damage and/or telomere shortening. Here, we investigate histone variant H2A.J as a new biomarker to detect senescent cells during human skin aging. Skin biopsies from healthy volunteers of different ages (18-90 years) were analyzed for H2A.J expression and other parameters involved in triggering and/or...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to melanin and skin pigmentation
Share to Skin Protection and Aging
Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33795696
DOI: 10.1038/s41514-021-00060-z

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human skin aging is associated with increased expression of the histone variant H2A.J in the epidermisPMID 33795696Read ↗

Histone variant H2A.J accumulates in senescent cells and promotes inflammatory gene expression.Semantic proximity Read ↗

Cultured Human Foreskin as a Model System for Evaluating Ionizing Radiation-Induced Skin InjurySemantic proximity Read ↗

Histone Variant H2A.J Marks Persistent DNA Damage and Triggers the Secretory Phenotype in Radiation-Induced Senescence.Semantic proximity Read ↗

The role of cellular senescence in skin aging and age-related skin pathologiesSemantic proximity Read ↗

The H2A.J histone variant contributes to Interferon-Stimulated Gene expression in senescence by its weak interaction with H1 and the derepression of repeated DNA sequencesSemantic proximity Read ↗

Mapping epidermal and dermal cellular senescence in human skin agingSemantic proximity Read ↗

Skin senescence—from basic research to clinical practiceSemantic proximity Read ↗

Biomarkers of Cellular Senescence and Skin AgingSemantic proximity Read ↗

Epigenetic Regulation of Skin Cells in Natural Aging and Premature Aging DiseasesSemantic proximity Read ↗

Faces of cellular senescence in skin agingSemantic proximity Read ↗

Ultraviolet Radiation‐Induced Skin Aging: The Role of DNA Damage and Oxidative Stress in Epidermal Stem Cell Damage Mediated Skin AgingSemantic proximity Read ↗

HDAC4/5 regulate epidermal barrier function by modulating the epigenetic landscape of human keratinocytesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.