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Reversing PROTAC-induced ASH2L degradation reactivates proliferation in senescent cells

2026-05-04

Abstract excerpt

Nucleosomes control access to gene promoters. Histone H3 lysine 4 tri-methylation, catalyzed by 6 KMT2 complexes, correlates with accessible promoters and gene expression. The catalytic activity of KMT2 enzymes depends on an obligatory core complex with ASH2L being an essential subunit. We find that PROTAC induced depletion of ASH2L reduces H3K4me3, deregulates gene expression and prevents proliferation. Upon prol...

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Identifiers and source

Literature Corpus work
79988336-8646-59fa-a22b-c63a3a3d3ef6
DOI
10.64898/2026.05.02.722411
Open publication

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Reversing PROTAC-induced ASH2L degradation reactivates proliferation in senescent cellsDOI 10.64898/2026.05.02.722411
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