Article
Characterization of systemic immunosuppression by IDH mutant glioma small extracellular vesicles.
Neuro-oncology - 1 Feb 2022
Ludwig Nils, Rao Aparna, Sandlesh Poorva, Yerneni Saigopalakrishna S, Swain Alexander D, Bullock Kristin M, Hansen Kim M, Zhang Xiaoran, Jaman Emade, Allen Jordan, Krueger Katharine, Hong Chang-Sook, Banks William A, Whiteside Theresa L, Amankulor Nduka M
Abstract excerpt
BACKGROUND: Gliomas are the most common primary brain tumors and are universally fatal. Mutations in the isocitrate dehydrogenase genes (IDH1 and IDH2) define a distinct glioma subtype associated with an immunosuppressive tumor microenvironment. Mechanisms underlying systemic immunosuppression in IDH mutant (mutIDH) gliomas are largely unknown. Here, we define genotype-specific local and systemic tumor...
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