Article

ADAM17 Deletion Protects Against Type1 Diabetes-Associated Kidney Injury by Modulating Inflammatory and Fibrotic Pathways

2026-02-08

Abstract excerpt

0 <h4>Background</h4> A Disintegrin and Metalloprotease 17 (ADAM17) is a key sheddase regulating multiple inflammatory and growth factor–related pathways implicated in diabetic kidney disease (DKD). While cell-specific deletion of ADAM17 has shown renoprotective effects, the impact of global ADAM17 ablation in the context of diabetes remains incompletely understood. <h4>Methods</h4> We investigated the effects o...

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Literature Corpus work: 2dce794e-7b34-5758-a9ae-5da4132a7e9a
DOI: 10.64898/2026.02.05.704041

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