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Article

Role of fibrillin-1 in hypertensive and diabetic glomerular disease.

American journal of physiology. Renal physiology - 1 Jun 2006

Hartner Andrea, Schaefer Liliana, Porst Markus, Cordasic Nada, Gabriel Anke, Klanke Bernd, Reinhardt Dieter P, Hilgers Karl F

Abstract excerpt

The microfibrillar protein fibrillin-1 is a component of the mesangial matrix. Defects in fibrillin-1 predisposes individuals to vascular damage in Marfan syndrome, but the role of fibrillin-1 in kidney disease is unknown. We hypothesized that fibrillin-1 is involved in hypertensive or diabetic glomerular disease. DOCA-salt hypertension or streptozotocin (STZ) diabetes led to a significant increase in glomerular...

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Identifiers

PMID: 16380460
DOI: 10.1152/ajprenal.00284.2005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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