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Article

ADAM17 mediates epidermal growth factor receptor transactivation and vascular smooth muscle cell hypertrophy induced by angiotensin II.

Arteriosclerosis, thrombosis, and vascular biology - 1 Sept 2006

Ohtsu Haruhiko, Dempsey Peter J, Frank Gerald D, Brailoiu Eugen, Higuchi Sadaharu, Suzuki Hiroyuki, Nakashima Hidekatsu, Eguchi Kunie, Eguchi Satoru

Abstract excerpt

BACKGROUND: Angiotensin II (Ang II) promotes growth of vascular smooth muscle cells (VSMCs) via epidermal growth factor (EGF) receptor (EGFR) transactivation mediated through a metalloprotease-dependent shedding of heparin-binding EGF-like growth factor (HB-EGF). However, the identity of the metalloprotease responsible for this process remains unknown. METHODS AND RESULTS: To identify the metalloprotease required...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Hypertrophy

Share to Muscle, Smooth, Vascular

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Share to Receptor, Angiotensin, Type 1

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Source

Identifiers

PMID: 16840716
DOI: 10.1161/01.ATV.0000236203.90331.d0

Genes

EGF
EGFR
ADAM17
ADAM10
JAK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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