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Article

Renal Protection by Genetic Deletion of the Atypical Chemokine Receptor ACKR2 in Diabetic OVE Mice.

Journal of diabetes research - 1 Jan 2016

Zheng Shirong, Coventry Susan, Cai Lu, Powell David W, Jala Venkatakrishna R, Haribabu Bodduluri, Epstein Paul N

Abstract excerpt

In diabetic nephropathy (DN) proinflammatory chemokines and leukocyte infiltration correlate with tubulointerstitial injury and declining renal function. The atypical chemokine receptor ACKR2 is a chemokine scavenger receptor which binds and sequesters many inflammatory CC chemokines but does not transduce typical G-protein mediated signaling events. ACKR2 is known to regulate diverse inflammatory diseases but...

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Age Factors
Albuminuria
Diabetic Nephropathies
Fibrosis
Gene Deletion

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptors, Chemokine

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Identifiers

PMID: 26798651
DOI: 10.1155/2016/5362506
PMCID: PMC4699014

Genes

ACKR2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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