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Article

Loss of TIMP3 underlies diabetic nephropathy via FoxO1/STAT1 interplay

12 Feb 2013

Abstract excerpt

ADAM17 and its inhibitor TIMP3 are involved in nephropathy, but their role in diabetic kidney disease (DKD) is unclear. Diabetic Timp3(-/-) mice showed increased albuminuria, increased membrane thickness and mesangial expansion. Microarray profiling uncovered a significant reduction of Foxo1 expression in diabetic Timp3(-/-) mice compared to WT, along with FoxO1 target genes involved in autophagy, while STAT1, a...

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PMID: 23401241
DOI: 10.1002/emmm.201201475

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