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Article

ADAM17 promotes proliferation of collecting duct kidney epithelial cells through ERK activation and increased glycolysis in polycystic kidney disease.

American journal of physiology. Renal physiology - 1 Sept 2014

Beck Gooz Monika, Maldonado Eduardo N, Dang Yujing, Amria May Y, Higashiyama Shigeki, Abboud Hanna E, Lemasters John J, Bell P Darwin

Abstract excerpt

Polycystic kidney disease (PKD) is a common genetic disorder leading to cyst formation in the kidneys and other organs that ultimately results in kidney failure and death. Currently, there is no therapy for slowing down or stopping the progression of PKD. In this study, we identified the disinteg...

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Source

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Identifiers

PMID: 24899059
DOI: 10.1152/ajprenal.00218.2014
PMCID: PMC4154111

Genes

ADAM17
EGF
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24899059-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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