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Article

Versatile Roles of the Chromatin Remodeler CHD7 during Brain Development and Disease

28 Sept 2017

Abstract excerpt

CHD7 (Chromo-Helicase-DNA binding protein 7) protein is an ATP-dependent chromatin remodeller. Heterozygous mutation of the CHD7 gene causes a severe congenital disease known as CHARGE syndrome. Most CHARGE syndrome patients have brain structural anomalies, implicating an important role of CHD7 during brain development. In this review, we summarize studies dissecting developmental functions of CHD7 in the brain...

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Identifiers

PMID: 29033785
DOI: 10.3389/fnmol.2017.00309

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Versatile Roles of the Chromatin Remodeler CHD7 during Brain Development and DiseasePMID 29033785Read ↗

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Autism‐linked CHD gene expression patterns during development predict multi‐organ disease phenotypesSemantic proximity Read ↗

Chromatin remodeller Chd7 is developmentally regulated in the neural crest by tissue-specific transcription factorsSemantic proximity Read ↗

Functional Insights into Chromatin Remodelling from Studies on CHARGE Syndrome.Semantic proximity Read ↗

Mutation update on the CHD7 gene involved in CHARGE syndrome.Semantic proximity Read ↗

Chromatin remodeller Chd7 is developmentally regulated in the neural crest by tissue-specific transcription factorsSemantic proximity Read ↗

CHD7 regulates cardiovascular development through ATP-dependent and -independent activities.Semantic proximity Read ↗

Multi-omic analyses identify molecular targets of Chd7 that contribute to CHARGE syndrome model phenotypes.Semantic proximity Read ↗

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Multi-omic analyses identify molecular targets of Chd7 that mediate CHARGE syndrome model phenotypesSemantic proximity Read ↗

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