Article

CHD3 Regulates BMP Signalling Response During Cranial Neural Crest Cell Specification

2025-02-19

Abstract excerpt

CHD3 is a component of the NuRD chromatin remodeling complex. Pathogenic _CHD3_ variants cause Snijders Blok-Campeau Syndrome, a neurodevelopmental disorder with variable features including developmental delays, intellectual disability, speech/language difficulties, and craniofacial anomalies. To unveil the role of CHD3 in craniofacial development, we differentiated _CHD3_-KO induced pluripotent stem cells into cr...

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Literature Corpus work: f030505a-73c6-5bfb-a15f-998d4d1abf27
DOI: 10.32388/tl3ebk

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