Article

DNA damage and nuclear morphological changes in cardiac hypertrophy are mediated by SNRK through actin depolymerization

2023-07-14

Abstract excerpt

<h4>BACKGROUND</h4> Proper nuclear organization is critical for cardiomyocyte (CM) function, as global structural remodeling of nuclear morphology and chromatin structure underpins the development and progression of cardiovascular disease. Previous reports have implicated a role for DNA damage in cardiac hypertrophy, however, the mechanism for this process is not well delineated. AMPK family of proteins regulate...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2dc4618f-6c5d-511d-a9e2-b73f9c10cd28
DOI: 10.1101/2023.07.14.549060

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

DNA damage and nuclear morphological changes in cardiac hypertrophy are mediated by SNRK through actin depolymerizationDOI 10.1101/2023.07.14.549060Read

DNA Damage and Nuclear Morphological Changes in Cardiac Hypertrophy Are Mediated by SNRK Through Actin DepolymerizationSemantic proximity Read

Ataxia Telangiectasia and Rad3-related protein (ATR) maintains cardiac tissue functionalitySemantic proximity Read

The nucleus activates mechano-responsiveness via FHOD-associated LINC complexesSemantic proximity Read

GATA4 regulates mitochondrial biogenesis and functions during cardiac development and rescues cardiac and mitochondrial functions impaired by TKIsSemantic proximity Read

SRPK3 regulates back-splicing of <i>pre-MYOCD</i> through Phosphorylating SRSF10 to modulate cardiac hypertrophySemantic proximity Read

BAG3 expression and sarcomere localization in the human heart are linked to HSF-1 and are differentially affected by sex and diseaseSemantic proximity Read

Regulation of the Balance between Concentric and Eccentric Cardiac Hypertrophy by a CDC14A-KMT5A Signaling PathwaySemantic proximity Read

TIGAR DEFICIENCY ENHANCES CARDIAC RESILIENCE THROUGH EPIGENETIC PROGRAMMING OF PARKIN EXPRESSIONSemantic proximity Read

SF3A2 deacetylation at lysin 10 mitigates myocardial pathological remodeling by reprogramming cardiomyocyte metabolismSemantic proximity Read

Sucrose Nonfermenting-Related Kinase Enzyme-Mediated Rho-Associated Kinase Signaling is Responsible for Cardiac Function.Semantic proximity Read

Sam68 Exacerbates Pathological Cardiac Hypertrophy by Suppressing Cardiomyocyte Glucose OxidationSemantic proximity Read

skNAC is a Key Driver of Cardiomyocyte Integrity Against Pathological Cardiac Hypertrophy and Heart FailureSemantic proximity Read