Article

The nucleus activates mechano-responsiveness via FHOD-associated LINC complexes

2025-06-15

Abstract excerpt

<h4>ABSTRACT</h4> The nucleus is the defining organelle of eukaryotic cells. It is usually considered a target organelle for cellular inputs. Here, we find that the nucleus is not simply a “passive” responder, but an active organelle directing the mechanical properties of the actin cytoskeleton it engages. Biochemically, interaction of FHOD formins with nesprin-2 of the nuclear LINC complex activates their actin...

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Literature Corpus work: 54b7b622-6bba-5171-93f6-e552de4b324c
DOI: 10.1101/2025.06.13.659598

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