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Article

BAG3 expression and sarcomere localization in the human heart are linked to HSF-1 and are differentially affected by sex and disease

14 May 2021

Abstract excerpt

Myofilament BAG3 expression decreases in male patients with nonischemic DCM but is preserved in female patients with DCM. BAG3 expression in the human heart is tightly linked to HSF-1 expression and nuclear translocation. HSF-1 localizes to the sarcomere Z-disc in the human heart. HSF-1 expression in the myofilament fraction decreases in male patients with DCM and positively correlates with myofilament BAG3.

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PMID: 33989081
DOI: 10.1152/ajpheart.00419.2020

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