Article

Sam68 Exacerbates Pathological Cardiac Hypertrophy by Suppressing Cardiomyocyte Glucose Oxidation

2025-02-03

Abstract excerpt

<h4>Background</h4> Impaired energy metabolism in the heart is critical in the development of cardiac hypertrophy and failure. Src-associated in mitosis 68 kDa (Sam68) is a member of the signal transducer and activator of RNA (STAR) protein family, and its role in cardiac energy metabolism is undefined. <h4>Methods</h4> We assessed Sam68 expression in human myopathic and failing hearts. We also generated mice with...

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Literature Corpus work: e27c71c7-aca5-5055-9c70-2105a0c6420e
DOI: 10.1101/2025.01.31.25321508

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