Article

3D structure and <i>in situ</i> arrangements of CatSper channel in the sperm flagellum

2021-06-20

Abstract excerpt

The sperm calcium channel CatSper plays a central role in successful fertilization as a primary Ca 2+ gateway into the sperm flagellum. However, CatSper’s complex subunit composition has impeded its reconstitution in vitro and structural elucidation. Here, we applied cryo-electron tomography to visualize the macromolecular organization of the native CatSper channel complex in intact mammalian sperm, as well as i...

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Literature Corpus work: 2d9772e6-ae93-554e-8c3c-9fdd34866d4a
DOI: 10.1101/2021.06.19.448910

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