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Article

A voltage-gated ion channel expressed specifically in spermatozoa

23 Oct 2001

Abstract excerpt

Calcium ions play a primary role in the regulation of sperm cell behavior. We report finding a voltage-gated ion channel (CatSper2) that is expressed in male germ cells but not in other cells. The putative channel contains 6 transmembrane segments, making it more similar to the voltage-gated potassium channels, but the ion selectivity pore domain sequence resembles that of a Ca(v) channel. The mRNA is expressed...

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PMID: 11675491
DOI: 10.1073/pnas.221454998

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