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3D structure and in situ arrangements of CatSper channel in the sperm flagellum

17 Jun 2022

Abstract excerpt

Abstract The sperm calcium channel CatSper plays a central role in successful fertilization as a primary Ca 2+ gateway. Here, we applied cryo-electron tomography to visualize the higher-order organization of the native CatSper complex in intact mammalian sperm. The repeating CatSper units form long zigzag-rows along mouse and human sperm flagella. Above each tetrameric channel pore, most of the extracellular...

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PMID: 35715406
DOI: 10.1038/s41467-022-31050-8

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