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Article

CatSperζ regulates the structural continuity of sperm Ca2+ signaling domains and is required for normal fertility

22 Feb 2017

Abstract excerpt

We report that the Gm7068 (CatSpere) and Tex40 (CatSperz) genes encode novel subunits of a 9-subunit CatSper ion channel complex. Targeted disruption of CatSperz reduces CatSper current and sperm rheotactic efficiency in mice, resulting in severe male subfertility. Normally distributed in linear quadrilateral nanodomains along the flagellum, the complex lacking CatSperζ is disrupted at ~0.8 μm intervals along the...

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PMID: 28226241
DOI: 10.7554/elife.23082

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